Please find below annual lists of the publications that took advantage of the services provided by Bioinformatics Center.

Klåvus, A.; Kokla, M.; Noerman, S.; Koistinen, V.M.; Tuomainen, M.; Zarei, I.; Meuronen, T.; Häkkinen, M.R.; Rummukainen, S.; Farizah Babu, A.; Sallinen, T.; Kärkkäinen, O.; Paananen, J.; Broadhurst, D.; Brunius, C.; Hanhineva, K. “notame”: Workflow for Non-Targeted LC–MS Metabolic Profiling. Metabolites 2020, 10, 135, https://doi.org/10.3390/metabo10040135

Das Gupta, S., Lipponen, A., Paldanius, K.M.A. et al. Dynamics of clusterin protein expression in the brain and plasma following experimental traumatic brain injury. Sci Rep 9, 20208 (2019), https://doi.org/10.1038/s41598-019-56683-6

Ngo Trong T, Mehtonen J, González G, Kramer R, Hautamäki V, Heinäniemi M. Semisupervised Generative Autoencoder for Single-Cell Data., J Comput Biol. 2019 Dec, https://doi.org/10.1089/cmb.2019.0337

Paananen, J; Fortino, V. An omics perspective on drug target discovery platforms., Brief Bioinform. 2019 Nov, https://doi.org/10.1093/bib/bbz122

Nikkilä A, Arvela H, Mehtonen J, Raitanen J, Heinäniemi M, Lohi O, Auvinen A. Predicting residential radon concentrations in Finland: Model development, validation, and application to childhood leukemia., Scand J Work Environ Health. 2019 Nov, https://doi.org/10.5271/sjweh.3867

Sallinen H, Janhonen S, Pölönen P, Niskanen H, Liu OH, Kivelä A, Hartikainen JM, Anttila M, Heinäniemi M, Ylä-Herttuala S, Kaikkonen MU. Comparative transcriptome analysis of matched primary and distant metastatic ovarian carcinoma., BMC Cancer. 2019 Nov 19, https://doi.org/10.1186/s12885-019-6339-0

Lipponen A, Natunen T, Hujo M, Ciszek R, Hämäläinen E, Tohka J, Hiltunen M, Paananen J, Poulsen D, Kansanen E, Ndode-Ekane XE, Levonen AL, Pitkänen A. In Vitro and In Vivo Pipeline for Validation of Disease-Modifying Effects of Systems Biology-Derived Network Treatments for Traumatic Brain Injury—Lessons Learned, Int. J. Mol. Sci. 2019 Oct, https://doi.org/10.3390/ijms20215395

Pölönen P, Jawahar Deen A, Leinonen HM, Jyrkkänen HK, Kuosmanen S, Mononen M, Jain A, Tuomainen T, Pasonen-Seppänen S, Hartikainen JM, Mannermaa A, Nykter M, Tavi P, Johansen T, Heinäniemi M, Levonen AL. Nrf2 and SQSTM1/p62 jointly contribute to mesenchymal transition and invasion in glioblastoma., Oncogene. 2019 Aug, https://doi.org/10.1038/s41388-019-0956-6

Benhammou JN, Ko A, Alvarez M, Kaikkonen MU, Rankin C, Garske KM, Padua D, Bhagat Y, Kaminska D, Kärjä V, Pihlajamäki J, Pisegna JR, Pajukanta P. Novel Lipid Long Intervening Noncoding RNA, Oligodendrocyte Maturation-Associated Long Intergenic Noncoding RNA, Regulates the Liver Steatosis Gene Stearoyl-Coenzyme A Desaturase As an Enhancer RNA., Hepatol Commun. 2019 Aug, https://doi.org/10.1002/hep4.1413

Kuusanmäki H, Leppä AM, Pölönen P, Kontro M, Dufva O, Deb D, Yadav B, Brück O, Kumar A, Everaus H, Gjertsen BT, Heinäniemi M, Porkka K, Mustjoki S, Heckman CA. Phenotype-based drug screening reveals association between venetoclax response and differentiation stage in acute myeloid leukemia., Haematologica. 2019 Jul, https://doi.org/10.3324/haematol.2018.214882

Failli M, Paananen J, Fortino V. Prioritizing target-disease associations with novel safety and efficacy scoring methods, Sci Rep 2019 Jul, https://doi.org/10.1038/s41598-019-46293-7

Pölönen P, Mehtonen J, Lin J, Liuksiala T, Häyrynen S, Teppo S, Mäkinen A, Kumar A, Malani D, Pohjolainen V, Porkka K, Heckman CA, May P, Hautamäki V, Granberg K, Lohi O, Nykter M, Heinäniemi M. Hemap: An interactive online resource for characterizing molecular phenotypes across hematologic malignancies, Cancer Research 2019 May, https://doi.org/10.1158/0008-5472.CAN-18-2970

Mehtonen J, Pölönen P, Häyrynen S, Lin J, Liuksiala T, Granberg K, Lohi O, Hautamäki V, Nykter M, Heinäniemi M. Data-driven characterization of molecular phenotypes across heterogenous sample collections, Nucleic Acids Research 2019 Apr, https://doi.org/10.1093/nar/gkz281

Marttinen M, Paananen J, Neme A, Mitra V, Takalo M, Natunen T, Paldanius KMA, Mäkinen P, Bremang M, Kurki MI, Rauramaa T, Leinonen V, Soininen H, Haapasalo A, Pike I, Hiltunen M A multiomic approach to characterize the temporal sequence in Alzheimer's disease-related pathology, Neurobiol Dis. 2019 Apr, https://doi.org/10.1016/j.nbd.2018.12.009

Jauhiainen S, Laakkonen JP, Ketola K, Toivanen PI, Nieminen T, Ninchoji T, Levonen AL, Kaikkonen MU, Ylä-Herttuala S. Axon Guidance-Related Factor FLRT3 Regulates VEGF-Signaling and Endothelial Cell Function., Front Physiol. 2019 Mar, https://doi.org/10.3389/fphys.2019.00224

Viiri LE, Rantapero T, Kiamehr M, Alexanova A, Oittinen M, Viiri K, Niskanen H, Nykter M, Kaikkonen MU, Aalto-Setälä K. Extensive reprogramming of the nascent transcriptome during iPSC to hepatocyte differentiation., Sci Rep., 2019 Mar, https://doi.org/10.1038/s41598-019-39215-0

Karttunen, J.; Heiskanen, M.; Lipponen, A.; Poulsen, D.; Pitkänen, A. Extracellular Vesicles as Diagnostics and Therapeutics for Structural Epilepsies, Int. J. Mol. Sci. 2019 Mar; https://doi.org/10.3390/ijms20061259

Gurzeler E, Aavik E, Laine A, Valkama T, Niskanen H, Huusko J, Kaikkonen MU, Ylä-Herttuala S. Therapeutic effects of rosuvastatin in hypercholesterolemic prediabetic mice in the absence of low density lipoprotein receptor., Biochim Biophys Acta Gen Subj., 2019 Feb, https://doi.org/10.1016/j.bbagen.2018.11.012

Timonen O, Särkkä M, Fülöp T, Mattsson A, Kekäläinen J, Paananen J. Varanto: variant enrichment analysis and annotation, Bioinformatics 2019 Jan, https://doi.org/10.1093/bioinformatics/btz046

Chen X, Ayala I, Shannon C, Fourcaudot M, Acharya NK, Jenkinson CP, Heikkinen S, Norton L. The Diabetes Gene and Wnt Pathway Effector TCF7L2 Regulates Adipocyte Development and Function, Diabetes 2018, https://doi.org/10.2337/db17-0318.

Niskanen H, Tuszynska I, Zaborowski R, Heinäniemi M, Ylä-Herttuala S, Wilczynski B, Kaikkonen MU.Endothelial cell differentiation is encompassed by changes in long range interactions between inactive chromatin regions Nucleic Acids Res. 2018, 10.1093/nar/gkx1214.

Lewis, JD, Evans, AC, Tohka J. T1 white/gray contrast as a predictor of chronological age, and an index of cognitive performance NeuroImage 2018, https://doi.org/10.1016/j.neuroimage.2018.02.050

Martiskainen H, Takalo M, Solomon A, Stančáková A, Marttinen M, Natunen T, Haapasalo A, Herukka SK, Kuusisto J, Soininen H, Kivipelto M, Laakso M, Hiltunen M. Decreased plasma C-reactive protein levels in APOE ε4 allele carriers, Ann Clin Transl Neurol. 2018. https://doi.org/10.1002/acn3.639.

Kaartokallio T, Utge S, Klemetti MM, Paananen J, Pulkki K, Romppanen J, Tikkanen I, Heinonen S, Kajantie E, Kere J, Kivinen K, Pouta A, Lakkisto P, Laivuori H. Fetal Microsatellite in the Heme Oxygenase 1 Promoter Is Associated With Severe and Early-Onset Preeclampsia , Hypertension 2018, https://doi.org/10.1161/HYPERTENSIONAHA.117.10425.

Paananen, J. Bioinformatics in the Identification of Novel Targets and Pathways in Neurodegenerative Diseases, Curr Genet Med Rep (2017) 5:15–21, https://doi.org/10.1007/s40142-017-0115-8